Cutaneous vasculitis following COVID-19 vaccination: a case-based review
-
Rama Bozorgmehr
,
Katayoun Enteshari
,
Arash Khameneh Bagheri
,
Reza Jafarzadeh Esfehani
,
Fahimeh Abdollahimajd
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging virus that causes a disease mainly known by its pulmonary and thrombotic complications. Although cutaneous complications, including vasculitis, have been reported in infected patients, the development of vasculitis after receiving vaccine is a rare clinical finding. Here, we report a case of vasculitis in a female patient who received a COVID-19 vaccine and was later infected with SARS-CoV-2, and was also diagnosed with hepatitis B during hospitalization. Our patient did not have a previous history of similar cutaneous manifestations of vasculitis, and the development of the symptoms approximately one month from the vaccination suggests immune complex hypersensitivity reaction.
1. Wijeratne T, Gillard Crewther S, Sales C, Karimi L. COVID-19 pathophysiology predicts that ischemic stroke occurrence is an expectation, not an exception—a systematic review. Front Neurol. 2021;11:607221.
2. Baigi V, Nedjat S, Yunesian M, Akbari Sari A, Mirzaee M, Allameh SF. Clinical and epidemiological features of hospitalized patients with COVID-19 in hospitals of Tehran University of Medical Sciences. Front Emerg Med. 2020;5(2):e20.
3. Hanff TC, Mohareb AM, Giri J, Cohen JB, Chirinos JA. Thrombosis in COVID‐19. Am J Hematol. 2020;95(12):1578-89.
4. Fatima F, Kumar P, Ghosh S, Das A. Post‐Covid cutaneous small‐vessel vasculitis with features of Koebnerization. J Cosmet Dermatol. 2021;00-1-2.
5. Shahidi Dadras M, Zargari O, Abolghasemi R, Bahmanjahromi A, Abdollahimajd F. A probable atypical skin manifestation of COVID-19 infection. J Dermatolog Treat. 2020:1-3.
6. Sun Q, Fathy R, McMahon DE, Freeman EE. COVID-19 Vaccines and the Skin: The Landscape of Cutaneous Vaccine Reactions Worldwide. Dermatol Clin. 2021;39(4):653-73.
7. McGonagle D, Bridgewood C, Ramanan AV, Meaney JF, Watad A. COVID-19 vasculitis and novel vasculitis mimics. Lancet Rheumatol. 2021;3(3):e224-33.
8. Ramadan SM, Kasfiki EV, Kelly CW, Ali I. An interesting case of small vessel pathology following coronavirus infection. BMJ Case Rep. 2020;13(9):e237407.
9. Cohen SR, Prussick L, Kahn JS, Gao DX, Radfar A, Rosmarin D. Leukocytoclastic vasculitis flare following the COVID-19 vaccine. Int J Dermatol. 2021;60(8):1032-3.
10. Larson V, Seidenberg R, Caplan A, Brinster NK, Meehan SA, Kim RH. Clinical and histopathological spectrum of delayed adverse cutaneous reactions following COVID-19 vaccination. J Cutan Pathol. 2022;49(1):34-41.
11. Mücke VT, Knop V, Mücke MM, Ochsendorf F, Zeuzem S. First description of immune complex vasculitis after COVID-19 vaccination with BNT162b2: a case report. BMC Infect Dis. 2021;21:958.
12. Goeser MR, Laniosz V, Wetter DA. A practical approach to the diagnosis, evaluation, and management of cutaneous small-vessel vasculitis. Am J Clin Dermatol. 2014;15(4):299-306.
13. Bryce C, Grimes Z, Pujadas E, Ahuja S, Beasley MB, Albrecht R, et al. Pathophysiology of SARS-CoV-2: targeting of endothelial cells renders a complex disease with thrombotic microangiopathy and aberrant immune response. The Mount Sinai COVID-19 autopsy experience. MedRxiv. 2020;Preprint.
2. Baigi V, Nedjat S, Yunesian M, Akbari Sari A, Mirzaee M, Allameh SF. Clinical and epidemiological features of hospitalized patients with COVID-19 in hospitals of Tehran University of Medical Sciences. Front Emerg Med. 2020;5(2):e20.
3. Hanff TC, Mohareb AM, Giri J, Cohen JB, Chirinos JA. Thrombosis in COVID‐19. Am J Hematol. 2020;95(12):1578-89.
4. Fatima F, Kumar P, Ghosh S, Das A. Post‐Covid cutaneous small‐vessel vasculitis with features of Koebnerization. J Cosmet Dermatol. 2021;00-1-2.
5. Shahidi Dadras M, Zargari O, Abolghasemi R, Bahmanjahromi A, Abdollahimajd F. A probable atypical skin manifestation of COVID-19 infection. J Dermatolog Treat. 2020:1-3.
6. Sun Q, Fathy R, McMahon DE, Freeman EE. COVID-19 Vaccines and the Skin: The Landscape of Cutaneous Vaccine Reactions Worldwide. Dermatol Clin. 2021;39(4):653-73.
7. McGonagle D, Bridgewood C, Ramanan AV, Meaney JF, Watad A. COVID-19 vasculitis and novel vasculitis mimics. Lancet Rheumatol. 2021;3(3):e224-33.
8. Ramadan SM, Kasfiki EV, Kelly CW, Ali I. An interesting case of small vessel pathology following coronavirus infection. BMJ Case Rep. 2020;13(9):e237407.
9. Cohen SR, Prussick L, Kahn JS, Gao DX, Radfar A, Rosmarin D. Leukocytoclastic vasculitis flare following the COVID-19 vaccine. Int J Dermatol. 2021;60(8):1032-3.
10. Larson V, Seidenberg R, Caplan A, Brinster NK, Meehan SA, Kim RH. Clinical and histopathological spectrum of delayed adverse cutaneous reactions following COVID-19 vaccination. J Cutan Pathol. 2022;49(1):34-41.
11. Mücke VT, Knop V, Mücke MM, Ochsendorf F, Zeuzem S. First description of immune complex vasculitis after COVID-19 vaccination with BNT162b2: a case report. BMC Infect Dis. 2021;21:958.
12. Goeser MR, Laniosz V, Wetter DA. A practical approach to the diagnosis, evaluation, and management of cutaneous small-vessel vasculitis. Am J Clin Dermatol. 2014;15(4):299-306.
13. Bryce C, Grimes Z, Pujadas E, Ahuja S, Beasley MB, Albrecht R, et al. Pathophysiology of SARS-CoV-2: targeting of endothelial cells renders a complex disease with thrombotic microangiopathy and aberrant immune response. The Mount Sinai COVID-19 autopsy experience. MedRxiv. 2020;Preprint.
| Files | ||
| Issue | Vol 6 No 3 (2022): Summer (July) | |
| Section | Case (report / study) | |
| DOI | 10.18502/fem.v6i3.9403 | |
| Keywords | ||
| COVID-19 Thrombosis Vaccination Vasculitis | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Bozorgmehr R, Enteshari K, Khameneh Bagheri A, Jafarzadeh Esfehani R, Abdollahimajd F. Cutaneous vasculitis following COVID-19 vaccination: a case-based review. Front Emerg Med. 2022;6(3):e41.
Downloads
Download data is not yet available.
