Pregnancy and Childbirth During COVID-19 Pandemic: A Case Series and Review of Literature


Introduction: In March 2020, the World Health Organization introduced the Coronavirus disease 2019 (COVID-19) pandemic as a global health concern and predicted that without any changes in the transmission process, the disease would reach its peak in April. Hence, it was not unreasonable to expect the referral of pregnant women in all trimesters. Since respiratory illnesses can increase the risk of infectious diseases and maternal mortality, it is justifiable to consider COVID-19-positive cases as high-risk pregnancies. Case presentation: The present study introduced six pregnant women with COVID-19 and discussed the points to consider in managing these patients. Conclusions: Pregnant women are at increased risk in all epidemics of infectious diseases due to their physiological and immunological changes. Moreover, the safety of the fetus is another important issue to consider.

1. Monteleone PA, Nakano M, Lazar V, Gomes AP, de Martin H, Bonetti TC. A review of initial data on pregnancy during the COVID-19 outbreak: implications for assisted reproductive treatments. JBRA Assist Reprod. 2020;24(2):219-25.
2. Sun G, Tang F, Peng M, Gao Y, Peng J, Xie H, et al. Clinical features and outcomes of pregnant women suspected of coronavirus disease 2019. J Infect. 2020;81(1):e40-4.
3. WHO. WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020 [Available from:].
4. Wong G, Liu W, Liu Y, Zhou B, Bi Y, Gao GF. MERS, SARS, and Ebola: the role of super-spreaders in infectious disease. Cell Host Microbe. 2015;18(4):398–401.
5. Siston AM, Rasmussen SA, Honein MA, Fry AM, Seib K, Callaghan WM, et al. Pandemic 2009 influenza A (H1N1) virus illness among pregnant women in the United States. JAMA. 2010;303(15):1517-25.
6. Saccone G, Carbone FI, Zullo F. The novel coronavirus (2019-nCoV) in pregnancy: What we need to know. Eur J Obstet Gynecol Reprod Biol. 2020; 249: 92-3.
7. Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395(10226):809-15.
8. Dashraath P, Wong JLJ, Lim MXK, Lim LM, Li S, Biswas A, et al. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gynecol. 2020;222(6):521-31.
9. Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DK, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill. 2020;25(3):2000045.
10. Li Y, Zhao R, Zheng S, Chen X, Wang J, Sheng X, et al. Lack of vertical transmission of severe acute respiratory syndrome coronavirus 2, China. Emerg Infect Dis. 2020;26(6):1335-6.
11. Alfaraj SH, Al-Tawfiq JA, Memish ZA. Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection during pregnancy: Report of two cases & review of the literature. J Microbiol Immunol Infect. 2019;52(3):501-3.
12. Paoli D, Pallotti F, Colangelo S, Basilico F, Mazzuti L, Turriziani O, et al. Study of SARS-CoV-2 in semen and urine samples of a volunteer with positive naso-pharyngeal swab. J Endocrinol Invest. 2020;43(12):1819-22.
13. Kong W, Agarwal PP. Chest imaging appearance of COVID-19 infection. Radiol Cardiothorac Imaging. 2020;2(1):e200028..
14. Abushouk AI, Taheri MS, Pooransari P, Mirbaha S, Rouhipour A, Baratloo A. Pregnancy screening before diagnostic radiography in emergency department; an educational review. Emergency. 2017;5(1):e60.
15. Schwartz DA. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes. Arch Pathol Lab Med. 2020;144(7):799-805.
16. Gao J, Tian Z, Yang X. Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Biosci Trends. 2020;14(1):72-3.
17. Zhang L, Jiang Y, Wei M, Cheng B, Zhou X, Li J, et al. Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province. Zhonghua Fu Chan Ke Za Zhi. 2020;55(3):166-71.
IssueVol 5 No 4 (2021): Autumn (October) QRcode
SectionOriginal article
DOI 10.18502/fem.v5i4.6696
COVID-19 Pandemics Parturition Pregnancy

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How to Cite
Rahmani S, Norkhomami S, Shahi B, Keykha M. Pregnancy and Childbirth During COVID-19 Pandemic: A Case Series and Review of Literature. Front Emerg Med. 5(4):e44.


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