Relationship of the systemic immuno-inflammation index and hematological inflammatory index with mortality and hospitalization in acute pancreatitis: a cross-sectional study

Abstract

Objective: This study was conducted to reveal the relationship of the hematological inflammatory index (HII) and systemic immuno-inflammation index (SII) with short-term and prolonged hospitalization in cases of acute pancreatitis. Methods: This single-center cross-sectional study was conducted in the emergency department (ED) of an educational hospital. The study population contained cases who untaken to the ED with acute pancreatitis between August 15, 2021, and May 15, 2022. Cases discharged from the ED, those referred to another center for hospitalization, and those with absent information were excluded from the study. The patients were grouped according to the length of hospital stay (expected and prolonged) and short-term mortality (survivor and died). We constructed a receiver operating characteristic (ROC) curve for short-term mortality and prolonged hospitalization and obtained the area under the curve (AUC) values for SII and HII. Results: One hundred seventy-seven patients were included in the study. There was no significant difference between the expected and prolonged hospitalization groups in the terms of SII and HII (P=0.649 and P=0.084, respectively). There was also no significant difference between the survivor and died groups in the terms of these indexes (P=0.070 for HII and P=0.138 for SII). The AUC values for the SII and HII in the prediction of 30-day mortality were 0.616 and 0.642, respectively. The AUC values for the SII and HII in the prediction of prolonged hospitalization were 0.580 and 0.642, respectively. Conclusion: The outcomes of the present study showed no significant difference among the expected and prolonged hospitalization groups or the survivor and died groups in the terms of SII and HII. We recommend the validation of our results in multicenter studies with larger samples.

1. Kokulu K, Günaydın YK, Akıllı NB, Köylü R, Sert ET, Köylü Ö, et al. Relationship between the neutrophil-to-lymphocyte ratio in acute pancreatitis and the severity and systemic complications of the disease. Turk J Gastroenterol. 2018;29(6):684-91.
2. Ge P, Luo Y, Okoye CS, Chen H, Liu J, Zhang G, et al. Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: a troublesome trio for acute pancreatitis. Biomed Pharmacother. 2020;132:110770.
3. Rau B, Poch B, Gansauge F, Bauer A, Nüssler AK, Nevalainen T, et al. Pathophysiologic role of oxygen free radicals in acute pancreatitis: initiating event or mediator of tissue damage? Ann Surg. 2000;231(3):352-60.
4. El Morsy EM, Ahmed MAE. Carvedilol attenuates l-arginine induced acute pancreatitis in rats through modulation of oxidative stress and inflammatory mediators. Chem Biol Interact. 2020;327:109181.
5. Sahinli H, Türker S. The hematologic inflammatory index is a new prognostic marker in patients resected for gastric cancer. J Cancer Res Ther. 2020;16(S):S144-9.
6. Öcal L, Keskin M, Cerşit S, Eren H, Özgün Çakmak E, Karagöz A, et al. Systemic immune-inflammation index predicts in-hospital and long-term outcomes in patients with ST-segment elevation myocardial infarction. Coron Artery Dis. 2022;33(4):251-60.
7. Krishna SG, Hinton A, Oza V, Hart PA, Swei E, El-Dika S, et al. Morbid obesity is associated with adverse clinical outcomes in acute pancreatitis: a propensity-matched study. Am J Gastroenterol. 2015;110(11):1608-19.
8. Williams M, Simms HH. Prognostic usefulness of scoring systems in critically ill patients with severe acute pancreatitis. Crit Care Med. 1999;27(5):901-7.
9. Miró Ò, Llorens P, Jiménez S, Piñera P, Burillo-Putze G, Martín A, et al. A case-control emergency department-based analysis of acute pancreatitis in Covid-19: results of the UMC-19-S6. J Hepatobiliary Pancreat Sci. 2021;28(11):953-66.
10. Koçkan E, Doğan NÖ, Pekdemir M, Yılmaz S, Yaka E. Predictors of prolonged hospitalization in patients with mild and moderate pancreatitis presenting to the emergency department. Med Klin Intensivmed Notfmed. 2022;117(6):459-65.
11. Fu CY, Yeh CN, Hsu JT, Jan YY, Hwang TL. Timing of mortality in severe acute pancreatitis: experience from 643 patients. World J Gastroenterol. 2007;13(13):1966-9.
12. Ong Y, Shelat VG. Ranson score to stratify severity in acute pancreatitis remains valid- old is gold. Expert Rev Gastroenterol Hepatol. 2021;15(8):865-77.
13. Kiyak M, Tanoglu A. Comparison of the efficacy of Balthazar score and C-reactive protein-albumin ratio for determination of acute pancreatitis severity. Curr Health Sci J. 2022;48(1):81-7.
14. Akoglu EU, Özdemir S, Ak R, Ozturk TC. The discriminative power of inflammatory markers in patients with mild-to-moderate acute pancreatitis: mean platelet volume, neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, and neutrophil-monocyte product. South Clin Ist Euras. 2021;32(2):159-64.
15. Altintas E, Koyuncu MB, Yaras S, Ucbilek E, Ates F, Sezgin O. Prognostic ability of hematological parameters and inflammation-based scores in acute pancreatitis. Jpn J Gastroenterol Hepatol. 2020;4:1-6.
16. Cifci M, Halhalli HC. The relationship between neutrophil-lymphocyte and platelet-lymphocyte ratios with hospital stays and mortality in the emergency department. Cureus. 2020;12(12):e12179.
17. Yarkaç A, Kose A, Bozkurt Babuş S, Ates F, Orekici Temel G, Ölmez A. The value of hematological parameters in acute pancreatitis. Ulus Travma Acil Cerrahi Derg. 2019;25(5):453-60.
18. Khan NA, Haider Kazmi SJ, Asghar MS, Singh M, Iqbal S, Jawed R, et al. Hematological indices predicting the severity of acute pancreatitis presenting to the emergency department: a retrospective analysis. Cureus. 2021;13(7):e16752.
19. Hu B, Yang XR, Xu Y, Sun YF, Sun C, Guo W, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014;20(23):6212-22.
20. Lu L, Feng Y, Liu YH, Tan HY, Dai GH, Liu SQ, et al. The systemic immune-inflammation index may be a novel and strong marker for the accurate early prediction of acute kidney injury in severe acute pancreatitis patients. J Invest Surg. 2022;35(5):962-6.
21. Özdemir S, Altunok İ, Özkan A, İslam MM, Algın A, Eroğlu SE, et al. The role of the hematological inflammatory index and systemic immuno-inflammation index in acute cholecystitis. Eur J Clin Exp Med. 2022;20(3):330–5.
22. Zhang D, Wang T, Dong X, Sun L, Wu Q, Liu J, et al. Systemic immune-inflammation index for predicting the prognosis of critically ill patients with acute pancreatitis. Int J Gen Med. 2021;14:4491-8.
Files
IssueVol 7 No 2 (2023): Spring (April) QRcode
SectionOriginal article
DOI 10.18502/fem.v7i2.12765
Keywords
Blood Platelets Lymphocytes Neutrophils Pancreatitis

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Özdemir S, Altunok İbrahim, Algın A. Relationship of the systemic immuno-inflammation index and hematological inflammatory index with mortality and hospitalization in acute pancreatitis: a cross-sectional study. Front Emerg Med. 2023;7(2):e13.

Downloads

Download data is not yet available.