Tehran University of Medical Sciences Frontiers in Emergency Medicine 2717-3593 5 2 2021 02 14 e25 e25 EN Gopikrishna Duvvada Department of Emergency Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar Ramkumar Swaminathane Department of Emergency Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar Thirumoorthy Samy Suresh Kumar Department of Emergency Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar 2021 01 23 2021 01 29 Allergic angina is not a rare disease, but it should be recognized at the earliest. We are reporting two cases of anaphylaxis, one with a history of unknown insect bite and the other due to intravenous (IV) contrast, leading to reversible myocardial ischemia, which we managed in our Emergency Department. These two patients clinically improved, and their ST-segment elevation on electrocardiogram (ECG) disappeared after intramuscular adrenaline. Allergic angina is an acute presentation in which anaphylaxis, or allergic insult, causes coronary spasm, which leads to angina. Early diagnosis and management initiation can minimize mortality and morbidity. https://fem.tums.ac.ir/index.php/fem/article/view/643 https://fem.tums.ac.ir/index.php/fem/article/download/643/343