Tehran University of Medical Sciences Frontiers in Emergency Medicine 2717-3593 8 3 2024 05 21 e29 e29 EN Hamideh Akbari Emergency Medicine Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Arash Safaei Department of Emergency Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Atousa Akhgar Emergency Medicine Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. 2024 02 20 2024 03 15 Coronavirus disease 2019 (COVID-19) is a transmissible disease instigated by the coronavirus (SARS-CoV-2) which has been identify for few years. Patients with COVID-19 may present with hypovolemia due to vomiting, anorexia, or diarrhea. However, treatment guidelines recommend a “conservative” fluid administration strategy with dynamic measuring parameters to assess fluid response. Since physical examination has a limited ability to predict volume status, other non-invasive methods such as point-of-care ultrasound (POCUS) have been extensively used for this purpose in other diseases. In this case series, we describe intravascular volume status in patients with moderate to severe COVID-19 as measured by inferior vena cava (IVC) calibre and distensibility. https://fem.tums.ac.ir/index.php/fem/article/view/1359 https://fem.tums.ac.ir/index.php/fem/article/download/1359/485