Tehran University of Medical Sciences Frontiers in Emergency Medicine 2717-3593 7 4 2023 12 09 e36 e36 Leili YekeFallah Department of Intensive Care Nursing, School of Nursing and Midwifery, Qazvin University of Medical Sciences, Qazvin, Iran Abbas Ahmadi School of Nursing and Midwifery, Qazvin University of Medical Sciences, Qazvin, Iran Ali Taromiha General Surgery Department, Shahid Rajaei Hospital, Qazvin University of Medical Sciences, Qazvin, Iran Narges Hoseyni Shahid Rajaei Hospital, Qazvin University of Medical Sciences, Qazvin, Iran Sareh Mohammadi Department of Intensive Care Nursing, Alborz University of Medical Sciences, Karaj, Iran 2023 08 02 2023 10 08 Objective:  The hypermetabolic response has undoubtedly evolved to help survive burns, but this physiological response has inconsistent consequences and increases the clinical consequences, such as increased heart work and ultimately its decline, decreased immune system function, risk of  sepsis, increased long-term  hospitalization, which increases the mortality of patients. This study aims to examine the effect of propranolol on post-traumatic stress disorder and clinical outcomes in burn patients. Methods:  This was an open-labeled randomized clinical trial in a single center with two parallel groups without placebo control. Propranolol was given 48 hours after starting of resuscitation. Results:  In this study, the burn wound of the patients who used propranolol healed faster. In addition, the administration of propranolol reduced the size of the burning surface, the size of the tissue required skin graft, the rejection rate of skin grafts, and also the length of stay in the hospital. Conclusion:  Using propranolol in treating burns can play an influential role in the recovery of burn patients,  and reduce the post-traumatic stress disorder. https://fem.tums.ac.ir/index.php/fem/article/view/1256 https://fem.tums.ac.ir/index.php/fem/article/download/1256/463