Tehran University of Medical Sciences Frontiers in Emergency Medicine 2717-3593 3 1 2018 11 29 e7 e7 Maryam Ziaei Department of Emergency Medicine, Khatam-Al-Anbia Hospital, Zahedan University of Medical Sciences, Zahedan, Iran Ali Massoudifar Department of Psychiatry, School of Medicine, Hormozgan University of Medical Sciences, Bandarabbas, Iran. Ali Rajabpour-Sanati Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran. Ali-Mohammad Pourbagher-Shahri Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran. Ali Abdolrazaghnejad Department of Emergency Medicine, Khatam-Al-Anbia Hospital, Zahedan University of Medical Sciences, Zahedan, Iran 2018 12 29 Context: The aim of this study is to reviewing various approaches for dealing with agitated patients in emergency department (ED) including of chemical and physical restraint methods. Evidence acquisition: This review was conducted by searching “Violence,” “Aggression,” and “workplace violence” keywords in these databases: PubMed, Scopus, EmBase, ScienceDirect, Cochrane Database, and Google Scholar. In addition to using keywords for finding the papers, the related article capability was used to find more papers. From the found papers, published papers from 2005 to 2018 were chosen to enter the paper pool for further review. Results: Ultimately, 200 papers were used in this paper to conduct a comprehensive review regarding violence management in ED. The results were categorized as prevention, verbal methods, pharmacological interventions and physical restraint. Conclusion: In this study various methods of chemical and physical restraint methods were reviewed so an emergency medicine physician be aware of various available choices in different clinical situations for agitated patients. https://fem.tums.ac.ir/index.php/fem/article/view/117 https://fem.tums.ac.ir/index.php/fem/article/download/117/96